THE 2-MINUTE RULE FOR PHENOBARBITAL USAGE

5. Phenytoin, sodium valproate, valproic acid: The effect of phenobarbital around the metabolism of phenytoin appears to get variable. Some investigators report an accelerating effect, even though others report no effect. As the effect of phenobarbital to the metabolism of phenytoin is just not predictable, phenytoin and phenobarbital blood levels